منابع مشابه
SV40: A Human Pathogen?
Over the past eight years an increasing number of investigators have found SV40 genomic sequences in a variety of human samples, both malignant and normal. Tumor types recurrently reported as SV40-positive include choroid plexus neoplasms, ependymomas, osteosarcomas, and mesotheliomas. Nonetheless, considerable skepticism that SV40 is a human pathogen still prevails. More constructively, the st...
متن کاملSimian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen
The ability to mount an immune response to simian virus 40 (SV40) T antigen was evaluated using mice from two distinct SV40 transgenic lines derived from injection of the same gene construct. Our studies demonstrate functional immune tolerance to SV40 T antigen in a SV40 transgenic line that consistently develops tumors of the choroid plexus by 7 mo of age. Antibodies to SV40 T antigen are unde...
متن کاملSimian Virus 40 (SV40) and Human Cancers
Simian virus 40 (SV40) contaminated the early poliovirus vaccines used throughout much of the world during the late 1950’s and early 1960’s. SV40 is oncogenic in rodents and can transform human cells in vitro. Most epidemiologic studies, however, have failed to detect increased risks of cancer among those exposed to SV40-contaminated poliovirus vaccines, even after more than 30 years of follow-...
متن کاملMutations in Nonastrocytic Human Brain Tumors
Genomic DNA from 51 primary human brain tumors was screened for the presence of mutations in the tumor suppressor gene, p53, using the polymerase chain reaction and single strand conformation polymorphism analysis, followed by direct DNA sequencing. Mutations leading to an amino acid change were found in 2 of 17 (12%) oligodendrogliomas and 2 of 19 (11%) medulloblastomas but none of 15 ependymo...
متن کامل[Uptake of bleomycin by human brain tumors].
Bleomycin (BLM), discovered by Umezawa et al. (1966a, b) is a kind of cytostatic antibiotic complex produced by a strain of Streptomyces verticillus, and was found by Ichikawa et al. (1967, 1968) to be highly effective against human squamous cell carcinoma. These authors observed relatively high concentration of BLM in the skin after subcutaneous injection in mice, and suggested that the therap...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2003
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.11189